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The Vitality 90+

The Vitality 90+ Study is a multidisciplinary project focusing on longevity and the oldest-old. The sub-projects address the biological basis of aging, predictors of health, functioning and longevity, old age as an individual experience, and the need for and use of care and services. The research is motivated by the rapid changes in the population structure and by the increase in real longevity. In Finland, the number of people aged 90 or older in 2012 is five times higher than 20 years ago, and by 2060 it will reach a quarter of a million.The Vitality 90+ Study was initiated in 1995 by professor Antti Hervonen.

Major research themes include

  • Health and functioning in the oldest-old and their time trends
  • Formal and informal care, services
  • Very old age as a stage of life; subjective experiences of long life
  • Biology of longevity, especially aging of the immune system

Data include

  • Mailed surveys with whole cohorts of people aged 90+ in Tampere
  • Face-to-face interviews and performance tests
  • Blood samples

Research group
Principal investigators
Marja Jylhä, Professor, marja.jylha@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University
Mikko Hurme, Professor (emeritus), mikko.hurme@tuni.fi, Faculty of Medicine and Health Technology, Tampere University
Antti Hervonen, Professor (emeritus), antti.hervonen(@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University

Seniors, post docs
Tapio Kirsi, tapio.kirsi@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University
Kirsi Lumme-Sandt, kirsi.lumme-sandt@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University
Kristina Tiainen, kristina.tiainen@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University

Doctoral student
Pauliina Halonen, pauliina.halonen@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University

Doctoral thesis
Linda Enroth, linda.enroth@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University Socioeconomic differences in health functioning and mortality in nonagenarians

Inna Lisko, inna.lisko@gmail.com, Faculty of Social Sciences (Health Sciences), Tampere University Association of body mass index and waist circumference with functional status and mortality in 90-year-old people

Saara Marttila, saara.marttila@liverpool.ac.uk, Faculty of Social Sciences (Health Sciences), Tampere University Genome-wide gene expression in immunosenescence

Lily Nosraty, lily.nosraty@tuni.fi, Faculty of Social Sciences (Health Sciences), Tampere University Successful aging in nonagenarians

Funding
Academy of Finland
Pirkanmaa Hospital District, competetive research fundingm
Funding from several sources 1995-

Publications

Hoogendijk, E. O; van der Noordt, M; Onwuteaka-Philipsen, Bregje D; Deeg, Dorly J.H; Huisman, M; Enroth, L; Jylhä; M. Sex differences in healthy life expectancy among nonagenarians: A multistate survival model using data from Vitality 90+ study. Experimental Gerontology 116 (2019) 80-85. DOI: 10.1016/j.exger.2018.12.015

Tuominen, Katariina & Pirhonen, Jari (2019). Who would take a 90-year-old? Community-dwelling nonagenarians’ perceptions of social relationships. International Journal of Ageing and Later Life, Advance access. DOI: http://doi.org/10.3384/ijal.1652-8670.18387

Enroth L, Aaltonen M, Raitanen J, Nosraty L & Jylhä M 2017. Does use of long-term care differ between occupational classes among the oldest old? Vitality 90+ Study. European Journal of Ageing. DOI: 10.1007/s10433-017-0445-0

Kauppi M, Raitanen J, Stenholm S, Aaltonen M, Enroth L & Jylhä M 2017. Predictors of long-term care among nonagenarians: the Vitality 90 + Study with linked data of the care registers. Aging Clinical and Experimental Research. DOI: 10.1007/s40520-017-0869-6

Nosraty L, Pulkki J, Raitanen J, Enroth L & Jylhä M 2017. Successful Aging as a Predictor of Long-Term Care Among Oldest Old: The Vitality 90+ Study. Journal of Applied Gerontology. DOI: 10.1177/0733464817716968

Lisko Inna, Tiainen Kristina, Raitanen Jani, Jylhävä Juulia, Hurme Mikko, Hervonen Antti, Stenholm Sari. (2017). Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study. Journals of Gerontology A 72 (11), 1569–1574.

Enroth L, Raitanen J, Hervonen A, Lehtimäki T, Jylhävä J, Hurme M & Jylhä M. 2015. Cardiometabolic and Inflammatory Biomarkers as Mediators between Educational Level and Functioning at the Age of 90 Years. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 70. doi: 10.1093/gerona/glv105

Enroth L, Raitanen J, Hervonen A, Nosraty L & Jylhä M. 2015. Is Socioeconomic Status a Predictor of Mortality in Nonagenarians? The Vitality 90+ Study. Age and Ageing 44, 123-129.

Nosraty L, Enroth L, Raitanen J, Hervonen A & Jylhä M. 2015. Do Successful Agers Live Longer? The Vitality 90+ Study. Journal of Aging and Health 27 (1), 35-53.

Lisko Inna, Stenholm Sari, Raitanen Jani, Hurme Mikko, Hervonen Antti, Jylhä Marja, Tiainen Kristiina. (2015). Association of Body Mass Index and Waist Circumference With Physical Functioning: The Vitality 90+ Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 70(7), 885-91.

Tiainen K, Luukkaala T, Hervonen A, Jylhä M. Predictors of mortality in men and women aged 90 years and older: nine-year follow-up. Age & Ageing 42:468-475, 2013. doi:10.1093/ageing/aft030t PubMed

Enroth L, Raitanen J, Hervonen A, Jylhä M. Do socioeconomic health differences persist in nonagenarians. J Gerontol Psych Sci Soc Sci. 68(5):837-847, 2013. doi: 10.1093/geronh/gbt067

Galenkamp H, Deeg DJH, Huisman M, Hervonen A, Braam AW, Jylhä M. Is self-rated health still sensitive for changes in disease and functioning among nonagenarians? J Gerontol Psych Sci Soc Sci 68(5):848-858. 2013. doi: 10.1093/geronh/gbt067

Jylha M. Enroth L and Luukkaala T. Trends of functioning and health in nonagenarians- the Vitality 90+ Study. In Robine JM, Jagger C, Crimmins E. Annual Review of Gerontology and Geriatrics, vol 33, 2013 ”Healthy Longevity”. Springer Publishing Company, pp- 313-332

Helminen S, Sarkeala T, Enroth L, Hervonen A, Jylhä M. Vanhoista vanhiimpien terveys ja elämätilanne. Tuloksia vuoden 201 Tervskannot 90+- tutkimuksesta. Gerontologia 26(3):162-171, 2012

Vuorisalmi M, Sarkeala T, Hervonen A, Jylhä M. Among nonagenarians, congruence between self-rated health and proxy-rated health was low but both predicted mortality. J Clin Epidemiol 65:553-559, 2012, doi: 10 1016/jclinepi.2011.11001

Jylhävä J, Jylhä M, Lehtimäki T, Hervonen A, Hurme M. Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians. Exp Gerontol 47(5);372-8,Epub 2012 Mar 3, PMID:22406558

Lisko I, Tiainen K, Stenholm S, Luukkaala T, Hurme M, Lehtimäki T, Hervonen A, Jylhä M. Inflammation, adiposity and mortality in the oldest old. Rejuvenation Research 15(5):445-452, 2012. DOI:10.1089/rej.2011.1310. Epub 2012 Sep 21

Nosraty L, Hervonen A, Jylhä M. Is there successful aging for nonagenarians? Vitality 90+ study. Journal of Aging Research, 2012;2012:868797. doi:10.1155/2012/868797. Epub 2012 Oct 16. PubMed PMID: 23125931

Sarkeala T, Nummi T, Vuorisalmi M, Hervonen A, JylhäM. Disability trends among nonagenarians in 2001-2007: Vitality 90 study. Eur J Ageing 8 (2) : 87-94, 2011 DOI 10.1007/s10433-011-0188-2.

Lisko I, Tiainen K, Stenholm S, Luukkaala T, Hervonen A, Jylhä M. Body mass index, waist circumference, and waist-to-hip ratio as predictors of mortality in nonagenarians: the Vitality 90+ Study. J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1244-50. Epub 2011 Aug 22. PubMed PMID: 21860016

Jylhävä J, Kotipelto T, Raitala A, Jylhä M, Hervonen A, Hurme M. Ageing is associated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ Study. Mech Ageing Dev 132:20-26, 2011, epub ahead of printing doi:10.1016/j.mad.2010.11.001

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