High running capacity is associated with health and longevity. However, whether high genetic running capacity promotes more efficient metabolism with aging is not known. A new study conducted in collaboration between the universities of Shanghai Jiao Tong University (China) and Jyv\u00e4skyl\u00e4 (Finland) investigated the effects of genetic running capacity and aging on tissue metabolism. The study reveals that adipose tissue may have a key role in healthy aging.<\/p>\n
Running capacity, expressed as aerobic capacity, refers to an individual\u2019s capacity to utilize oxygen and is known to decrease with age, thereby affecting the whole body metabolism and health.<\/p>\n
\u201cWe currently lack the information whether high genetic aerobic capacity promotes healthier metabolism in different tissues as we age,\u201d explains Academy of Finland postdoctoral researcher Sira Karvinen\u00a0<\/strong>from the Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Finland.<\/p>\n To study the question, animal models of high-capacity runners (HCR) and low-capacity runners (LCR) were utilized. These rodent lines differ in their aerobic capacity genetically. Samples of serum, muscle and adipose tissue were harvested from young and aged animals to explore the tissue metabolites.<\/p>\n \u201cAccording to our results, high genetic running capacity was associated with more efficient amino acid metabolism in skeletal muscle. Inefficient amino acid metabolism is linked to increased adiposity and risk of metabolic diseases,\u201d says Karvinen.<\/p>\n High genetic running capacity and aging interactively affected lipid metabolism in muscle and adipose tissue, possibly contributing to healthier metabolism with aging.<\/p>\n The results suggest that adipose tissue may have a more significant role in promoting healthy aging than previously thought. According to the current literature, around 50% of an individual\u2019s aerobic capacity is genetically inherited and the other 50% can be gained via physical activity.<\/p>\n \u201cRegular exercise promotes health whether you have genetically high or low aerobic capacity. Hence, it is highly recommended to promote one\u2019s metabolism with exercise especially at older age, when aerobic capacity as well as other health parameters decline,\u201d says the principal investigator, Professor Heikki Kainulainen<\/strong> from the Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Finland.<\/p>\n The study was carried out in collaboration between Shanghai Jiao Tong University (China) and Jyv\u00e4skyl\u00e4 University (Finland) and was funded by the Academy of Finland, Biocenter Finland, HILIFE, Finnish Government Scholarship Pool, EVO research grant, Shanghai Jiao Tong University and Zhiyuan Foundation, China Postdoc Scholarship and National Institutes of Health (NIH, USA).<\/p>\n Haihui Zhuang, Sira Karvinen, Timo T\u00f6rmakangas, Xiaobo Zhang, Xiaowei Ojanen, Vidya Velagapudi, Markku Alen, Steven L. Britton, Lauren G. Koch, Heikki Kainulainen, Sulin Cheng, Petri Wiklund. Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue.<\/a> GeroScience, published 5 June 2020.<\/p>\n Contact:<\/strong><\/p>\n Sira Karvinen,\u00a0sira.m.karvinen@jyu.fi,\u00a0<\/a>+358503625120<\/p>\n","protected":false,"raw":"High running capacity is associated with health and longevity. However, whether high genetic running capacity promotes more efficient metabolism with aging is not known. A new study conducted in collaboration between the universities of Shanghai Jiao Tong University (China) and Jyv\u00e4skyl\u00e4 (Finland) investigated the effects of genetic running capacity and aging on tissue metabolism. The study reveals that adipose tissue may have a key role in healthy aging.\r\n\r\nRunning capacity, expressed as aerobic capacity, refers to an individual\u2019s capacity to utilize oxygen and is known to decrease with age, thereby affecting the whole body metabolism and health.\r\n\r\n\u201cWe currently lack the information whether high genetic aerobic capacity promotes healthier metabolism in different tissues as we age,\u201d explains Academy of Finland postdoctoral researcher Sira Karvinen\u00a0<\/strong>from the Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Finland.\r\n\r\nTo study the question, animal models of high-capacity runners (HCR) and low-capacity runners (LCR) were utilized. These rodent lines differ in their aerobic capacity genetically. Samples of serum, muscle and adipose tissue were harvested from young and aged animals to explore the tissue metabolites.\r\n\r\n\u201cAccording to our results, high genetic running capacity was associated with more efficient amino acid metabolism in skeletal muscle. Inefficient amino acid metabolism is linked to increased adiposity and risk of metabolic diseases,\u201d says Karvinen.\r\n\r\nHigh genetic running capacity and aging interactively affected lipid metabolism in muscle and adipose tissue, possibly contributing to healthier metabolism with aging.\r\n\r\nThe results suggest that adipose tissue may have a more significant role in promoting healthy aging than previously thought. According to the current literature, around 50% of an individual\u2019s aerobic capacity is genetically inherited and the other 50% can be gained via physical activity.\r\n\r\n\u201cRegular exercise promotes health whether you have genetically high or low aerobic capacity. Hence, it is highly recommended to promote one\u2019s metabolism with exercise especially at older age, when aerobic capacity as well as other health parameters decline,\u201d says the principal investigator, Professor Heikki Kainulainen<\/strong> from the Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Finland.\r\n\r\nThe study was carried out in collaboration between Shanghai Jiao Tong University (China) and Jyv\u00e4skyl\u00e4 University (Finland) and was funded by the Academy of Finland, Biocenter Finland, HILIFE, Finnish Government Scholarship Pool, EVO research grant, Shanghai Jiao Tong University and Zhiyuan Foundation, China Postdoc Scholarship and National Institutes of Health (NIH, USA).\r\nOriginal article:<\/strong><\/h4>\n
Original article:<\/strong><\/h4>\r\nHaihui Zhuang, Sira Karvinen, Timo T\u00f6rmakangas, Xiaobo Zhang, Xiaowei Ojanen, Vidya Velagapudi, Markku Alen, Steven L. Britton, Lauren G. Koch, Heikki Kainulainen, Sulin Cheng, Petri Wiklund. Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue.<\/a> GeroScience, published 5 June 2020.\r\n\r\nContact:<\/strong>\r\n\r\nSira Karvinen,\u00a0sira.m.karvinen@jyu.fi,\u00a0<\/a>+358503625120"},"excerpt":{"rendered":"Juoksukyky kertoo terveydest\u00e4 ja ennustaa odotettavissa olevia elinvuosia. Toistaiseksi ei tiedet\u00e4, miss\u00e4 m\u00e4\u00e4rin perinn\u00f6llinen juoksukyky vaikuttaa kehon aineenvaihduntaan ik\u00e4\u00e4ntymisen yhteydess\u00e4. Jyv\u00e4skyl\u00e4n ja Shanghain yliopistojen yhteisty\u00f6n\u00e4 tehty tutkimus selvitti perim\u00e4n ja ik\u00e4\u00e4ntymisen vaikutuksia eri kudosten aineenvaihduntaan ja havaitsi, ett\u00e4 rasvakudoksella voi…","protected":false,"raw":""},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_fi_post_content":"
Alkuper\u00e4inen tutkimusartikkeli:<\/strong><\/h4>\r\nHaihui Zhuang, Sira Karvinen, Timo T\u00f6rmakangas, Xiaobo Zhang, Xiaowei Ojanen, Vidya Velagapudi, Markku Alen, Steven L. Britton, Lauren G. Koch, Heikki Kainulainen, Sulin Cheng, Petri Wiklund. Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue.<\/a> GeroScience, published 5 June 2020.\r\n
Lis\u00e4tietoja:<\/h4>\r\nTutkijatohtori Sira Karvinen, sira.m.karvinen@jyu.fi, 050 3625120\r\n\r\n<\/div>\r\n<\/div>\r\n<\/div>","_fi_post_name":"hyva-juoksukyky-edistaa-tehokasta-aineenvaihduntaa-myos-ikaantyessa","_fi_post_excerpt":"","_fi_post_title":"Hyv\u00e4 juoksukyky edist\u00e4\u00e4 tehokasta aineenvaihduntaa my\u00f6s ik\u00e4\u00e4ntyess\u00e4","_en_post_content":"High running capacity is associated with health and longevity. However, whether high genetic running capacity promotes more efficient metabolism with aging is not known. A new study conducted in collaboration between the universities of Shanghai Jiao Tong University (China) and Jyv\u00e4skyl\u00e4 (Finland) investigated the effects of genetic running capacity and aging on tissue metabolism. The study reveals that adipose tissue may have a key role in healthy aging.\r\n\r\nRunning capacity, expressed as aerobic capacity, refers to an individual\u2019s capacity to utilize oxygen and is known to decrease with age, thereby affecting the whole body metabolism and health.\r\n\r\n\u201cWe currently lack the information whether high genetic aerobic capacity promotes healthier metabolism in different tissues as we age,\u201d explains Academy of Finland postdoctoral researcher Sira Karvinen\u00a0<\/strong>from the Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Finland.\r\n\r\nTo study the question, animal models of high-capacity runners (HCR) and low-capacity runners (LCR) were utilized. These rodent lines differ in their aerobic capacity genetically. Samples of serum, muscle and adipose tissue were harvested from young and aged animals to explore the tissue metabolites.\r\n\r\n\u201cAccording to our results, high genetic running capacity was associated with more efficient amino acid metabolism in skeletal muscle. Inefficient amino acid metabolism is linked to increased adiposity and risk of metabolic diseases,\u201d says Karvinen.\r\n\r\nHigh genetic running capacity and aging interactively affected lipid metabolism in muscle and adipose tissue, possibly contributing to healthier metabolism with aging.\r\n\r\nThe results suggest that adipose tissue may have a more significant role in promoting healthy aging than previously thought. According to the current literature, around 50% of an individual\u2019s aerobic capacity is genetically inherited and the other 50% can be gained via physical activity.\r\n\r\n\u201cRegular exercise promotes health whether you have genetically high or low aerobic capacity. Hence, it is highly recommended to promote one\u2019s metabolism with exercise especially at older age, when aerobic capacity as well as other health parameters decline,\u201d says the principal investigator, Professor Heikki Kainulainen<\/strong> from the Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Finland.\r\n\r\nThe study was carried out in collaboration between Shanghai Jiao Tong University (China) and Jyv\u00e4skyl\u00e4 University (Finland) and was funded by the Academy of Finland, Biocenter Finland, HILIFE, Finnish Government Scholarship Pool, EVO research grant, Shanghai Jiao Tong University and Zhiyuan Foundation, China Postdoc Scholarship and National Institutes of Health (NIH, USA).\r\n
Original article:<\/strong><\/h4>\r\nHaihui Zhuang, Sira Karvinen, Timo T\u00f6rmakangas, Xiaobo Zhang, Xiaowei Ojanen, Vidya Velagapudi, Markku Alen, Steven L. Britton, Lauren G. Koch, Heikki Kainulainen, Sulin Cheng, Petri Wiklund. Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue.<\/a> GeroScience, published 5 June 2020.\r\n\r\nContact:<\/strong>\r\n\r\nSira Karvinen,\u00a0sira.m.karvinen@jyu.fi,\u00a0<\/a>+358503625120","_en_post_name":"high-genetic-running-capacity-promotes-efficient-metabolism-with-aging","_en_post_excerpt":"","_en_post_title":"High genetic running capacity promotes efficient metabolism with aging","edit_language":"en","footnotes":""},"categories":[130],"tags":[227,431,432],"class_list":["post-8153","post","type-post","status-publish","format-standard","hentry","category-tiedeuutiset","tag-ageing","tag-high-running-capacity","tag-metabolism","entry","no-media"],"_links":{"self":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/posts\/8153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/comments?post=8153"}],"version-history":[{"count":3,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/posts\/8153\/revisions"}],"predecessor-version":[{"id":8156,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/posts\/8153\/revisions\/8156"}],"wp:attachment":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/media?parent=8153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/categories?post=8153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/tags?post=8153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}