{"id":8033,"date":"2021-04-20T09:56:26","date_gmt":"2021-04-20T06:56:26","guid":{"rendered":"https:\/\/www.gerec.fi\/?p=8033"},"modified":"2021-05-10T10:29:42","modified_gmt":"2021-05-10T07:29:42","slug":"age-at-the-menopause-can-be-assessed-using-predictive-modeling","status":"publish","type":"post","link":"https:\/\/www.gerec.fi\/en\/age-at-the-menopause-can-be-assessed-using-predictive-modeling\/","title":{"rendered":"Age at the menopause can be assessed using predictive modeling","raw":"Age at the menopause can be assessed using predictive modeling"},"content":{"rendered":"

The age at menopause is known to vary significantly between individuals and it has been associated with postmenopausal health. In a recent study, the researchers developed two models for predicting the age at natural menopause. The results of the study indicated that sex hormone levels, irregular menstrual cycles, menopausal symptoms, and life habits can be used for predicting the age at menopause.<\/strong><\/p>\n

The natural menopause occurs when the menstrual periods cease due to the naturally decreased ovary function. There is a significant interindividual variation in the age at natural menopause but, on average, women undergo it around the age of 51 in Western countries. Furthermore, the length of the preceding menopausal transition, characterized by irregular menstrual cycles and menopausal symptoms, is also known to vary between individuals.<\/p>\n

The study revealed that higher estradiol and follicle-stimulating hormone levels, irregular menstrual cycles, and menopausal symptoms are strong indicators of approaching menopause in middle-aged women. Additionally, information related to life habits, such as physical activity, alcohol consumption, and smoking, may provide useful information for assessing the time to natural menopause.<\/p>\n

After the menopause, women can no longer get pregnant naturally, but the age at menopause has also been associated with the risk of several public health concerns such as cardiovascular disease, cancer, and osteoporosis.<\/p>\n

\u201cThe prediction of the age at natural menopause is beneficial for health promotion with middle-aged and elderly women but it could also be useful for women making decisions related to family planning and treatments for menopausal symptoms,\u201d explains doctoral researcher Matti Hyv\u00e4rinen<\/strong> from the Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4.<\/p>\n

The predictive models constructed in the study demonstrated adequate prediction accuracy with absolute errors of slightly over 6 months between the predicted and observed age at natural menopause in middle-aged women.<\/p>\n

According to Hyv\u00e4rinen, the results indicate that the approach used in the study may be used to develop a tool for assessing the age at natural menopause also for women in their 30s or early 40s in the future.<\/p>\n

The study was carried out in the Gerontology Research Center and Faculty of Sport and Health Science at the University of Jyv\u00e4skyl\u00e4, Finland. It was part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study<\/a> led by Academy Research Fellow Eija Laakkonen<\/strong>. The participants in the ERMA study were women between the ages of 47 and 55 living in the Jyv\u00e4skyl\u00e4 region at the baseline. Participants that were perimenopausal during the baseline measurements were invited to the follow-up study, which included laboratory visits every 3 to 6 months until the participant was categorized as postmenopausal. The research has been funded by the Academy of Finland, European Commission, and Juho Vainio Foundation.<\/p>\n

Original article:\u00a0<\/strong><\/p>\n

Hyv\u00e4rinen, M., Karvanen, J., Aukee, P., Tammelin T. H., Sipil\u00e4, S., Kujala, U. M., Kovanen, V., Rantalainen, T. & Laakkonen, E. K. Predicting the Age at Natural Menopause in Middle-Aged Women. Menopause<\/a>, April 12, 2021.<\/p>\n

Contact:<\/strong><\/p>\n

Doctoral Student Matti Hyv\u00e4rinen, matti.v.hyvarinen@jyu.fi, +358 50 5358691
\nAcademy Research Fellow Eija Laakkonen, eija.k.laakkonen@jyu.fi, +358 40 8053588<\/p>\n

 <\/p>\n","protected":false,"raw":"The age at menopause is known to vary significantly between individuals and it has been associated with postmenopausal health. In a recent study, the researchers developed two models for predicting the age at natural menopause. The results of the study indicated that sex hormone levels, irregular menstrual cycles, menopausal symptoms, and life habits can be used for predicting the age at menopause.<\/strong>\r\n\r\nThe natural menopause occurs when the menstrual periods cease due to the naturally decreased ovary function. There is a significant interindividual variation in the age at natural menopause but, on average, women undergo it around the age of 51 in Western countries. Furthermore, the length of the preceding menopausal transition, characterized by irregular menstrual cycles and menopausal symptoms, is also known to vary between individuals.\r\n\r\nThe study revealed that higher estradiol and follicle-stimulating hormone levels, irregular menstrual cycles, and menopausal symptoms are strong indicators of approaching menopause in middle-aged women. Additionally, information related to life habits, such as physical activity, alcohol consumption, and smoking, may provide useful information for assessing the time to natural menopause.\r\n\r\nAfter the menopause, women can no longer get pregnant naturally, but the age at menopause has also been associated with the risk of several public health concerns such as cardiovascular disease, cancer, and osteoporosis.\r\n\r\n\u201cThe prediction of the age at natural menopause is beneficial for health promotion with middle-aged and elderly women but it could also be useful for women making decisions related to family planning and treatments for menopausal symptoms,\u201d explains doctoral researcher Matti Hyv\u00e4rinen<\/strong> from the Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4.\r\n\r\nThe predictive models constructed in the study demonstrated adequate prediction accuracy with absolute errors of slightly over 6 months between the predicted and observed age at natural menopause in middle-aged women.\r\n\r\nAccording to Hyv\u00e4rinen, the results indicate that the approach used in the study may be used to develop a tool for assessing the age at natural menopause also for women in their 30s or early 40s in the future.\r\n\r\nThe study was carried out in the Gerontology Research Center and Faculty of Sport and Health Science at the University of Jyv\u00e4skyl\u00e4, Finland. It was part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study<\/a> led by Academy Research Fellow Eija Laakkonen<\/strong>. The participants in the ERMA study were women between the ages of 47 and 55 living in the Jyv\u00e4skyl\u00e4 region at the baseline. Participants that were perimenopausal during the baseline measurements were invited to the follow-up study, which included laboratory visits every 3 to 6 months until the participant was categorized as postmenopausal. The research has been funded by the Academy of Finland, European Commission, and Juho Vainio Foundation.\r\n\r\nOriginal article:\u00a0<\/strong>\r\n\r\nHyv\u00e4rinen, M., Karvanen, J., Aukee, P., Tammelin T. H., Sipil\u00e4, S., Kujala, U. M., Kovanen, V., Rantalainen, T. & Laakkonen, E. K. Predicting the Age at Natural Menopause in Middle-Aged Women. Menopause<\/a>, April 12, 2021.\r\n\r\nContact:<\/strong>\r\n\r\nDoctoral Student Matti Hyv\u00e4rinen, matti.v.hyvarinen@jyu.fi, +358 50 5358691\r\nAcademy Research Fellow Eija Laakkonen, eija.k.laakkonen@jyu.fi, +358 40 8053588\r\n\r\n "},"excerpt":{"rendered":"Menopaussin ajankohdan tiedet\u00e4\u00e4n olevan hyvin yksil\u00f6llinen, ja sen on havaittu olevan yhteydess\u00e4 naisten terveyteen vaihdevuosien j\u00e4lkeen. Tuoreessa Jyv\u00e4skyl\u00e4n yliopiston tutkimuksessa todettiin sukupuolihormonitasojen, ep\u00e4s\u00e4\u00e4nn\u00f6llisten kuukautisten, vaihdevuosioireiden ja el\u00e4m\u00e4ntapatekij\u00f6iden ennustavan luonnollisen menopaussin ajankohtaa. Tutkijat tekiv\u00e4t kaksi ennustemallia, joiden avulla voidaan arvioida tulevan…","protected":false,"raw":""},"author":1,"featured_media":8034,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_fi_post_content":"

Menopaussin ajankohdan tiedet\u00e4\u00e4n olevan hyvin yksil\u00f6llinen, ja sen on havaittu olevan yhteydess\u00e4 naisten terveyteen vaihdevuosien j\u00e4lkeen. Tuoreessa Jyv\u00e4skyl\u00e4n yliopiston tutkimuksessa todettiin sukupuolihormonitasojen, ep\u00e4s\u00e4\u00e4nn\u00f6llisten kuukautisten, vaihdevuosioireiden ja el\u00e4m\u00e4ntapatekij\u00f6iden ennustavan luonnollisen menopaussin ajankohtaa. Tutkijat tekiv\u00e4t kaksi ennustemallia, joiden avulla voidaan arvioida tulevan menopaussin ajankohtaa.<\/strong><\/h4>\r\nLuonnollinen menopaussi tarkoittaa ajankohtaa naisen el\u00e4m\u00e4ss\u00e4, jolloin kuukautiset loppuvat munasarjojen toiminnan luonnollisen heikkenemisen seurauksena. L\u00e4nsimaissa se tapahtuu keskim\u00e4\u00e4rin 51 vuoden i\u00e4ss\u00e4, mutta ajankohta on hyvin yksil\u00f6llinen ja vaihtelee 40:n ja 60:n ik\u00e4vuoden v\u00e4lill\u00e4. My\u00f6s menopaussia edelt\u00e4v\u00e4 siirtym\u00e4vaihe, jolloin kuukautiset muuttuvat ep\u00e4s\u00e4\u00e4nn\u00f6llisiksi ja vaihdevuosioireiden kokeminen yleistyy, on pituudeltaan yksil\u00f6llinen.\r\n\r\nTutkimuksessa havaittiin, ett\u00e4 korkeammat sukupuolihormonitasot (estradioli ja FSH), ep\u00e4s\u00e4\u00e4nn\u00f6lliset kuukautiset ja vaihdevuosioireiden kokeminen ennustavat l\u00e4hestyv\u00e4\u00e4 menopaussia. Lis\u00e4ksi el\u00e4m\u00e4ntapamuuttujien, kuten fyysisen aktiivisuuden, alkoholink\u00e4yt\u00f6n ja tupakoinnin, lis\u00e4\u00e4minen malliin paransi tehtyjen mallien ennustemallien tarkkuutta, vaikka n\u00e4m\u00e4 kaikki eiv\u00e4t t\u00e4ss\u00e4 tutkimuksessa olleetkaan tilastollisesti merkitsev\u00e4sti yhteydess\u00e4 menopaussin ajankohtaan.\r\n
\r\n
\r\n
\r\n
\r\n\r\nMenopaussi ei vaikuta ainoastaan naisen mahdollisuuksiin tulla raskaaksi, vaan sen ajankohta on yhteydess\u00e4 my\u00f6s muun muassa syd\u00e4n- ja verisuonitautien, monien sy\u00f6pien ja osteoporoosin riskiin.\r\n\r\n- Vaikka tulevan menopaussin ajankohdan m\u00e4\u00e4ritt\u00e4minen tarkasti on vaikeaa, likim\u00e4\u00e4r\u00e4inenkin arvio siit\u00e4 voi olla eritt\u00e4in hy\u00f6dyllinen. Menopaussin ennakointia tarvitaan terveyteen, perhesuunnitteluun ja vaihdevuosioireiden hoitoon liittyviss\u00e4 kysymyksiss\u00e4, kertoo v\u00e4it\u00f6skirjatutkija\u00a0Matti Hyv\u00e4rinen\u00a0<\/strong>Gerontologian tutkimuskeskuksesta Jyv\u00e4skyl\u00e4n yliopiston liikuntatieteellisest\u00e4 tiedekunnasta.\r\n\r\nTutkimuksessa muodostettujen ennustemallien avulla menopaussin ajankohta pystyttiin ennustamaan keskim\u00e4\u00e4rin noin puolen vuoden tarkkuudella tutkimukseen osallistuneille keski-ik\u00e4isille naisille.\r\n\r\n- Kehitettyj\u00e4 ennustemalleja voidaan tulevaisuudessa soveltaa esimerkiksi vaihdevuosilaskurin muodostamiseen, jonka avulla my\u00f6s nuoremmat naiset voisivat arvioida tulevan menopaussin ajankohtaa, Hyv\u00e4rinen sanoo.\r\n\r\nTutkimus toteutettiin Gerontologian tutkimuskeskuksessa Jyv\u00e4skyl\u00e4n yliopiston liikuntatieteellisess\u00e4 tiedekunnassa osana laajempaa\u00a0Estrogeeni, vaihdevuodet ja toimintakyky (ERMA) -tutkimusta<\/a>, jota johtaa akatemiatutkija\u00a0Eija Laakkonen.<\/strong>\u00a0ERMA-tutkimuksen osallistujat olivat 47\u201355-vuotiaita Jyv\u00e4skyl\u00e4n seudulla asuvia naisia. Vaihdevuosien siirtym\u00e4vaiheessa olleet naiset kutsuttiin seurantatutkimukseen, jossa he k\u00e4viv\u00e4t mittauksissa 3\u20136 kuukauden v\u00e4lein, kunnes heid\u00e4n todettiin ohittaneen vaihdevuodet. Tutkimusprojektia ovat rahoittaneet Suomen Akatemia, Euroopan komissio ja Juho Vainion s\u00e4\u00e4ti\u00f6\r\n

Alkuper\u00e4inen tutkimusartikkeli:<\/strong><\/h3>\r\nHyv\u00e4rinen, M., Karvanen, J., Aukee, P., Tammelin T. H., Sipil\u00e4, S., Kujala, U. M., Kovanen, V., Rantalainen, T. & Laakkonen, E. K.\u00a0Predicting the Age at Natural Menopause in Middle-Aged Women<\/a>. Menopause, April 12, 2021.\r\n

Lis\u00e4tietoja:<\/strong><\/h3>\r\n