{"id":7443,"date":"2020-05-25T12:03:58","date_gmt":"2020-05-25T09:03:58","guid":{"rendered":"https:\/\/www.gerec.fi\/?p=7443"},"modified":"2020-06-08T14:08:04","modified_gmt":"2020-06-08T11:08:04","slug":"liikunta-hidastaa-vaihdevuosien-hormonimuutoksista-johtuvaa-lihasmassan-vahentymista","status":"publish","type":"post","link":"https:\/\/www.gerec.fi\/en\/liikunta-hidastaa-vaihdevuosien-hormonimuutoksista-johtuvaa-lihasmassan-vahentymista\/","title":{"rendered":"Hormonal changes during menopause decrease muscle mass, but physical activity might slow the decrement","raw":"Hormonal changes during menopause decrease muscle mass, but physical activity might slow the decrement"},"content":{"rendered":"

A large study of middle-aged women shows that age-related changes in skeletal muscle are part of everyday life for women in their fifties. During this time, women transition from perimenopause to postmenopause and the production of estrogen ceases. Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. Physical activity in all of its forms may help maintain muscle mass in midlife.<\/strong><\/p>\n

\u201cWe already knew that estrogen has a role in the regulation of muscle properties,\u201d says doctoral student Hanna-Kaarina Juppi. \u201cBy following the hormonal status, measuring many aspects of muscles and by taking into consideration the simultaneous chronological aging of women going through menopausal transition, we were able to show that the decrease of muscle mass takes place already in early postmenopause.\u201d<\/p>\n

In the current study, muscle size was measured in the perimenopausal state and right after entering postmenopause, when menstruation had permanently stopped. Women were on average 51-and-a-half years old at the beginning of the study and 53 years old at the final measurements, so the average duration of menopausal transition was one-and-a-half years. The time it takes a woman to go through menopause is unique: in this study it varied from less than six months to more than three years. During this time, the decrease in muscle mass was on average one percent.<\/p>\n

Juppi continues: \u201cThe observed change does not seem like much, but what is meaningful is that the decline happens in a short period of time and can have an impact on metabolism, as muscles are important regulators of whole-body metabolism.\u201d
\nPhysical activity was found to be positively associated with the maintenance of muscle mass during the menopausal transition. Women who were more active had higher muscle mass before and after menopause compared to the less active women. It seems that even though menopause alone decreases muscle mass, staying physically active throughout middle age can help women to slow the change.<\/p>\n

The current study was conducted in the Gerontology Research Center and Faculty of Sport and Health Sciences, and is part of a larger study, Estrogenic Regulation of Muscle Apoptosis (ERMA)<\/a>, led by Academy Research Fellow Eija Laakkonen. More than a thousand women between the ages of 47 and 55 from the Jyv\u00e4skyl\u00e4 region participated in the ERMA study. At the beginning of the study, 381 of them were perimenopausal, while 234 reached early postmenopause during the study. The research was funded by the Academy of Finland and the European Commission.<\/p>\n

Original article (open access):<\/strong><\/h4>\n

Juppi, H.-K., Sipil\u00e4, S., Cronin, N.J., Karvinen, S., Karppinen, J.E., Tammelin, T.H., Aukee, P., Kovanen, V., Kujala, U.M., Laakkonen, E.K. Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women. J. Clin. Med. 2020, 9, 1588. https:\/\/www.mdpi.com\/724112<\/a><\/p>\n

More information:<\/strong><\/h4>\n

Doctoral student Hanna-Kaarina Juppi, hanna.k.juppi@jyu.fi, p. +358 40 1945755
\nAcademy Research Fellow Eija Laakkonen, eija.k.laakkonen@jyu.fi, p. +358 40 8053588<\/p>\n","protected":false,"raw":"A large study of middle-aged women shows that age-related changes in skeletal muscle are part of everyday life for women in their fifties. During this time, women transition from perimenopause to postmenopause and the production of estrogen ceases. Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. Physical activity in all of its forms may help maintain muscle mass in midlife.<\/strong>\r\n\r\n\u201cWe already knew that estrogen has a role in the regulation of muscle properties,\u201d says doctoral student Hanna-Kaarina Juppi. \u201cBy following the hormonal status, measuring many aspects of muscles and by taking into consideration the simultaneous chronological aging of women going through menopausal transition, we were able to show that the decrease of muscle mass takes place already in early postmenopause.\u201d\r\n\r\nIn the current study, muscle size was measured in the perimenopausal state and right after entering postmenopause, when menstruation had permanently stopped. Women were on average 51-and-a-half years old at the beginning of the study and 53 years old at the final measurements, so the average duration of menopausal transition was one-and-a-half years. The time it takes a woman to go through menopause is unique: in this study it varied from less than six months to more than three years. During this time, the decrease in muscle mass was on average one percent.\r\n\r\nJuppi continues: \u201cThe observed change does not seem like much, but what is meaningful is that the decline happens in a short period of time and can have an impact on metabolism, as muscles are important regulators of whole-body metabolism.\u201d\r\nPhysical activity was found to be positively associated with the maintenance of muscle mass during the menopausal transition. Women who were more active had higher muscle mass before and after menopause compared to the less active women. It seems that even though menopause alone decreases muscle mass, staying physically active throughout middle age can help women to slow the change.\r\n\r\nThe current study was conducted in the Gerontology Research Center and Faculty of Sport and Health Sciences, and is part of a larger study, Estrogenic Regulation of Muscle Apoptosis (ERMA)<\/a>, led by Academy Research Fellow Eija Laakkonen. More than a thousand women between the ages of 47 and 55 from the Jyv\u00e4skyl\u00e4 region participated in the ERMA study. At the beginning of the study, 381 of them were perimenopausal, while 234 reached early postmenopause during the study. The research was funded by the Academy of Finland and the European Commission.\r\n

Original article (open access):<\/strong><\/h4>\r\nJuppi, H.-K., Sipil\u00e4, S., Cronin, N.J., Karvinen, S., Karppinen, J.E., Tammelin, T.H., Aukee, P., Kovanen, V., Kujala, U.M., Laakkonen, E.K. Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women. J. Clin. Med. 2020, 9, 1588. https:\/\/www.mdpi.com\/724112<\/a>\r\n

More information:<\/strong><\/h4>\r\nDoctoral student Hanna-Kaarina Juppi, hanna.k.juppi@jyu.fi, p. +358 40 1945755\r\nAcademy Research Fellow Eija Laakkonen, eija.k.laakkonen@jyu.fi, p. +358 40 8053588"},"excerpt":{"rendered":"Laaja keski-ik\u00e4isi\u00e4 naisia koskeva tutkimus osoittaa lihasten ik\u00e4\u00e4ntymismuutosten kuuluvan viisikymppisten naisten arkip\u00e4iv\u00e4\u00e4n. Silloin naiset siirtyv\u00e4t esivaihdevuosien kautta menopaussiin, jolloin naissukuhormoni estrogeenin tuotanto pys\u00e4htyy. T\u00e4m\u00e4 vaikuttaa my\u00f6s lihaksiin ja johtaa lihasmassan v\u00e4hentymiseen. Liikunta kuitenkin auttaa yll\u00e4pit\u00e4m\u00e4\u00e4n lihaksia my\u00f6s vaihdevuosi-i\u00e4ss\u00e4.   Kehonkoostumuksen…","protected":false,"raw":""},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_fi_post_content":"
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\r\n\r\nLaaja keski-ik\u00e4isi\u00e4 naisia koskeva tutkimus osoittaa lihasten ik\u00e4\u00e4ntymismuutosten kuuluvan viisikymppisten naisten arkip\u00e4iv\u00e4\u00e4n. Silloin naiset siirtyv\u00e4t esivaihdevuosien kautta menopaussiin, jolloin naissukuhormoni estrogeenin tuotanto pys\u00e4htyy. T\u00e4m\u00e4 vaikuttaa my\u00f6s lihaksiin ja johtaa lihasmassan v\u00e4hentymiseen. Liikunta kuitenkin auttaa yll\u00e4pit\u00e4m\u00e4\u00e4n lihaksia my\u00f6s vaihdevuosi-i\u00e4ss\u00e4.<\/strong>\r\n\r\n \r\n\r\n<\/div>\r\n<\/header>\r\n
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\r\n\r\nKehonkoostumuksen muutos \u2013 osa lihamassasta korvautuu rasvalla \u2013 kuuluu tavanomaiseen ik\u00e4\u00e4ntymiseen. Naisten lihakset pienentyv\u00e4t jonkun verran aikaisemmin kuin miesten. T\u00e4m\u00e4n on arveltu liittyv\u00e4n vaihdevuosien hormonimuutokseen, mutta ilmi\u00f6t\u00e4 on vaikea erottaa tavallisesta ik\u00e4\u00e4ntymisest\u00e4 ilman siihen suunniteltua pitkitt\u00e4istutkimusta.\r\n\r\n\u2013 Tiesimme, ett\u00e4 estrogeeni osallistuu lihasten ominaisuuksien s\u00e4\u00e4telyyn. Seuraamalla esivaihdevuosista menopaussiin siirtyvien naisten hormonitoimintaa, mittaamalla eri menetelmi\u00e4 k\u00e4ytt\u00e4en, mit\u00e4 lihaksille tapahtuu, ja huomioimalla analyyseiss\u00e4 kronologinen ik\u00e4\u00e4ntyminen pystyimme osoittamaan lihasmassan v\u00e4hentyv\u00e4n jo varhaisessa menopaussissa, kertoo tohtorikoulutettava Hanna-Kaarina Juppi<\/strong> Jyv\u00e4skyl\u00e4n yliopiston liikuntatieteellisest\u00e4 tiedekunnasta.\r\n\r\nTutkimuksessa lihasten koko mitattiin silloin, kun naiset olivat viel\u00e4 esivaihdevuosivaiheessa, ja mahdollisimman pian sen j\u00e4lkeen, kun kuukautiset ovat pysyv\u00e4sti loppuneet eli nainen on siirtynyt menopaussiin. Keskim\u00e4\u00e4rin tutkimuksessa mukana olleet naiset ehtiv\u00e4t ik\u00e4\u00e4nty\u00e4 noin puolitoista vuotta 51,5-vuotiaasta 53-vuotiaaksi. Vaihdevuosien siirtym\u00e4vaihe on kuitenkin yksil\u00f6llinen: toisilla siirtym\u00e4 kesti alle puoli vuotta, toisilla yli kolme vuotta. T\u00e4n\u00e4 aikana lihasmassa v\u00e4heni keskim\u00e4\u00e4rin noin prosentin.\r\n\r\n\u2013 Havaittu muutos ei kuulosta suurelta. Merkityksellist\u00e4 on, ett\u00e4 muutos tapahtuu nopeasti ja voi koko kehon tasolla vaikuttaa haitallisesti aineenvaihduntaan, sill\u00e4 lihakset ovat t\u00e4rke\u00e4 kehon aineenvaihdunnan yll\u00e4pit\u00e4j\u00e4, Juppi tarkentaa.\r\n\r\nTutkimuksessa fyysisen aktiivisuuden havaittiin vaikuttavan positiivisesti lihasmassan s\u00e4ilymiseen my\u00f6s vaihdevuosien aikana. Naisilla, jotka harrastivat enemm\u00e4n liikuntaa tutkimuksen aikana, oli suurempi lihasmassa ennen ja j\u00e4lkeen vaihdevuosien kuin niill\u00e4 naisilla, jotka liikkuivat v\u00e4hemm\u00e4n. Vaihdevuodet v\u00e4hent\u00e4v\u00e4t lihasmassaa, mutta pysym\u00e4ll\u00e4 fyysisesti aktiivisena muutokseen voi vaikuttaa.\r\n\r\nTutkimus toteutettiin osana laajempaa Jyv\u00e4skyl\u00e4n yliopiston Gerontologian tutkimuskeskuksen ja liikuntatieteellisen tiedekunnan Estrogeeni, vaihdevuodet ja toimintakyky- eli ERMA-tutkimusta<\/a>, jota johtaa akatemiatutkija Eija Laakkonen<\/strong>. ERMA-tutkimukseen on osallistunut yli tuhat 47-55 -vuotiasta Jyv\u00e4skyl\u00e4ss\u00e4 tai l\u00e4hiseudulla asuvaa naista. Heist\u00e4 381 oli tutkimuksen alussa esivaihdevuosivaiheessa ja 234 ehti seurannan aikana siirty\u00e4 vaihdevuosien siirtym\u00e4vaiheen yli varhaiseen postmenopaussiin. Tutkimusprojektia on rahoittanut Suomen Akatemia ja Euroopan komissio.\r\n

Alkuper\u00e4inen tutkimusartikkeli:<\/strong><\/h4>\r\nJuppi, H.-K., Sipil\u00e4, S., Cronin, N.J., Karvinen, S., Karppinen, J.E., Tammelin, T.H., Aukee, P., Kovanen, V., Kujala, U.M., Laakkonen, E.K. Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women. J. Clin. Med. 2020, 9, 1588. https:\/\/www.mdpi.com\/724112<\/a>\r\n

Lis\u00e4tietoja:<\/h4>\r\n