Study subjects include both pre- and postmenopausal women as well as identical postmenopausal twin pairs discordant for HRT i.e. the other twin uses HRT for several years while the co-twin has never used HRT. Body composition, muscle-related phenotype data, as well as muscle, adipose tissue and blood samples (whole blood, serum, plasma, leukocytes) \u00a0\u00a0are available from the women. In addition to conventional cell and molecular biological and biochemical analyses also high through-put techniques like gene expression arrays, miRNA arrays, epigenomic, proteomic and metabonomic analyses are done or ongoing.<\/p>\n
Research collaboration within this study entity includes Finnish researchers at Universities Helsinki, Oulu, Kuopio and Jyv\u00e4skyl\u00e4 and internationally at Universities Uppsala, Padova, Ancona and Paris via MYOAGE and ENGAGE research consortia (EU\/FP7). The HRT specific knowledge, both in relation to sarcopenia and other health outcomes will add our understanding, when evaluating the possible positive and negative effects of HRT. This study will increase our knowledge of the genetic and molecular mechanisms behind sarcopenia and responsiveness to interventions upon aging. Consequently, the results are crucial for developing rational preventive and therapeutic measures and interventions for old age disability, which can be applied e.g. at health and rehabilitation centers.<\/p>\n
Funding<\/strong> Research group<\/strong> Doctoral thesis<\/a><\/strong><\/p>\n Selected publications <\/strong><\/p>\n Collaborators Tutkimuksen tarkoituksena on selvitt\u00e4\u00e4 geeni- ja molekyylitasolla ik\u00e4\u00e4ntyv\u00e4n lihaksen toimintakyvyn heikkenemiseen liittyvi\u00e4 mekanismeja ja vaihdevuosioireisiin k\u00e4ytett\u00e4v\u00e4n estrogeenia sis\u00e4lt\u00e4v\u00e4n hormonikorvaus-hoidon (HRT) vaikutuksia n\u00e4ihin ilmi\u00f6ihin. Tutkimuksen kohteena on erityisesti lihas- ja rasvakudoksen v\u00e4linen vuorovaikutus ik\u00e4\u00e4ntyess\u00e4 ja HRT:n yhteydess\u00e4.<\/p>\r\n Tutkittavina on sek\u00e4 pre- ett\u00e4 postmenopausaalisia naisia. Erityinen tutkittavien ryhm\u00e4 on vaihdevuosi-i\u00e4n ohittanut 54\u201362 vuotiaiden identtisten kaksossiskojen ryhm\u00e4, jossa sisaret ovat HRT:n suhteen diskordantteja. Kaikille tutkittaville on tehty laajat lihasten ja kehon koostumuksen ja lihasten toimintakyvyn mittaukset sek\u00e4 terveydentilan, ravitsemuksen ja liikunta-aktiivisuuden kyselyt. Tutkittavilta on otettu lihas- ja rasvakudosn\u00e4ytteet sek\u00e4 verin\u00e4ytteet (koko veri, seerumi, plasma ja valkosolut). Tutkimusn\u00e4ytteist\u00e4 on tehty\/tehd\u00e4\u00e4n perinteisten solu- ja molekyylibiologisten ja biokemiallisten analyysien lis\u00e4ksi laajat koko perim\u00e4n kattavat geeniekspressio-, mikroRNA- ja DNA:n metylaatioanalyysit sek\u00e4 proteomiikka ja metabonomiikka-analyysit.<\/p>\r\n Tutkimusta tehd\u00e4\u00e4n yhteisty\u00f6ss\u00e4 Helsingin, Oulun, Kuopion ja Jyv\u00e4skyl\u00e4n yliopistoissa ty\u00f6skentelevien tutkimusryhmien kanssa. Osa SAWEs-tutkimuksen sis\u00e4ll\u00f6ist\u00e4 kuuluu MYOAGE ja ENGAGE konsortioihin (EU\/FP7). T\u00e4m\u00e4n kansainv\u00e4lisen yhteisty\u00f6n kautta mahdollistuvat mm. koko perim\u00e4n kattavat mikroRNA- tutkimukset (Bolognan ja Anconan yliopistot, Italia; MYOAGE) sek\u00e4 DNA:n metylaatioanalyysit osana ENGAGE-konsortion epigenetiikkatutkimusta (Uppsalan yliopisto, Ruotsi).<\/p>\r\n Tutkimuksemme tuo merkitt\u00e4v\u00e4\u00e4 uutta tietoa HRT:n vaikutuksista sek\u00e4 lihaksistoon ett\u00e4 muuhun terveyteen ja my\u00f6t\u00e4vaikuttaa siten HRT:n hy\u00f6tyjen ja haittojen arviointiin. Erityisesti aivan uutta tietoa saadaan geeni- ja molekyylitason mekanismeista, jotka selitt\u00e4v\u00e4t ik\u00e4\u00e4ntymiseen liittyv\u00e4\u00e4 lihasheikkoutta. N\u00e4m\u00e4 tiedot edesauttavat j\u00e4rkevien ennalta ehk\u00e4isevien ja kuntouttavien toimenpiteiden kehitt\u00e4mist\u00e4 i\u00e4kk\u00e4iden ihmisten toimintakyvyn yll\u00e4pit\u00e4miseksi.<\/p>\r\n Rahoittajat<\/strong>\r\n<\/b>Opetusministeri\u00f6, Suomen Akatemia, MYOAGE<\/p>\r\n Tutkimusryhm\u00e4<\/strong>\r\n<\/b>Vastuullinen tutkija\r\nDosentti, FT Vuokko Kovanen, terveystieteiden laitos, Jyv\u00e4skyl\u00e4n yliopisto<\/p>\r\n V\u00e4it\u00f6skirjat<\/a><\/strong><\/p>\r\n Keskeiset julkaisut<\/strong><\/p>\r\n\r\n Yhteisty\u00f6tahoja<\/strong>\r\n<\/b>Helsingin yliopisto (Jaakko Kaprio)\r\nIt\u00e4- Suomen yliopisto (Markku Tammi)\r\nOulun yliopisto (Mika Ala-Korpela)\r\nMYOAGE-konsortio (EU\/FP7)\r\nBolognan yliopisto, Italia (Claudio Franceschi)\r\nAnconan yliopisto, Italia (Antonio Procopio)\r\nUppsalan yliopisto, Ruotsi (Lars Larsson)\r\nENGAGE konsortio (EU\/FP\/)\r\nHelsingin yliopisto (Jaakko Kaprio)\r\nUppsalan yliopisto (Ann-Christine Syv\u00e4nen)<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n[\/vc_column_text][\/vc_column][\/vc_row]","_fi_post_name":"estrogeeni-ja-naisten-ikaantymiseen-liittyva-lihasheikkous-sawe","_fi_post_excerpt":"","_fi_post_title":"Estrogeeni ja naisten ik\u00e4\u00e4ntymiseen liittyv\u00e4 lihasheikkous (SAWEs)","_en_post_content":"[vc_row][vc_column][vc_column_text]The aim is to improve understanding of detailed molecular and physiological mechanisms responsible for the maintenance of healthy muscles with advancing age in women more prone to age-related muscle wasting and associated problems than same age men. We investigate the effects of and associations with estrogen-based hormone replacement therapy (HRT) and muscle characteristics and body composition in postmenopausal women in order to explore estrogen and other steroid hormones as molecular mechanism for aging-induced muscle weakness. Especially the muscle-fat cross-talk will be in focus.\r\n\r\nStudy subjects include both pre- and postmenopausal women as well as identical postmenopausal twin pairs discordant for HRT i.e. the other twin uses HRT for several years while the co-twin has never used HRT. Body composition, muscle-related phenotype data, as well as muscle, adipose tissue and blood samples (whole blood, serum, plasma, leukocytes) \u00a0\u00a0are available from the women. In addition to conventional cell and molecular biological and biochemical analyses also high through-put techniques like gene expression arrays, miRNA arrays, epigenomic, proteomic and metabonomic analyses are done or ongoing.\r\n\r\nResearch collaboration within this study entity includes Finnish researchers at Universities Helsinki, Oulu, Kuopio and Jyv\u00e4skyl\u00e4 and internationally at Universities Uppsala, Padova, Ancona and Paris via MYOAGE and ENGAGE research consortia (EU\/FP7). The HRT specific knowledge, both in relation to sarcopenia and other health outcomes will add our understanding, when evaluating the possible positive and negative effects of HRT. This study will increase our knowledge of the genetic and molecular mechanisms behind sarcopenia and responsiveness to interventions upon aging. Consequently, the results are crucial for developing rational preventive and therapeutic measures and interventions for old age disability, which can be applied e.g. at health and rehabilitation centers.\r\n\r\nFunding<\/strong>\r\nFinnish Ministry of Culture and Education, Academy of Finland, MYOAGE\r\n\r\nResearch group<\/strong>\r\nPrincipal Investigator<\/i>\r\nAdjunct professor, PhD Vuokko Kovanen, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\n\r\nDoctoral thesis<\/a><\/strong>\r\n\r\nSelected publications <\/strong>\r\n
\nFinnish Ministry of Culture and Education, Academy of Finland, MYOAGE<\/p>\n
\nPrincipal Investigator<\/i>
\nAdjunct professor, PhD Vuokko Kovanen, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4<\/p>\n\n
\n<\/strong>University of Helsinki (Jaakko Kaprio)
\nUniversity of Eastern Finland (Markku Tammi)
\nUniversity of Oulu (Mika Ala-Korpela)
\nMYOAGE-consortio (EU;FP7)
\nUniversity of Bologna, Italy (Claudio Franceschi)
\nUnivesrsity of Ancona, Italy (Antonio Procopio)
\nUniversity of Uppsala, Sweden (Lars Larsson)
\nENGAGE- consortio (EU\/FP7)
\nUniversity of Helsinki (Jaakko Kaprio)
\nUniversity of Uppsala, Sweden (Ann-Christine Syv\u00e4nen)[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false,"raw":"[vc_row][vc_column][vc_column_text]The aim is to improve understanding of detailed molecular and physiological mechanisms responsible for the maintenance of healthy muscles with advancing age in women more prone to age-related muscle wasting and associated problems than same age men. We investigate the effects of and associations with estrogen-based hormone replacement therapy (HRT) and muscle characteristics and body composition in postmenopausal women in order to explore estrogen and other steroid hormones as molecular mechanism for aging-induced muscle weakness. Especially the muscle-fat cross-talk will be in focus.\r\n\r\nStudy subjects include both pre- and postmenopausal women as well as identical postmenopausal twin pairs discordant for HRT i.e. the other twin uses HRT for several years while the co-twin has never used HRT. Body composition, muscle-related phenotype data, as well as muscle, adipose tissue and blood samples (whole blood, serum, plasma, leukocytes) \u00a0\u00a0are available from the women. In addition to conventional cell and molecular biological and biochemical analyses also high through-put techniques like gene expression arrays, miRNA arrays, epigenomic, proteomic and metabonomic analyses are done or ongoing.\r\n\r\nResearch collaboration within this study entity includes Finnish researchers at Universities Helsinki, Oulu, Kuopio and Jyv\u00e4skyl\u00e4 and internationally at Universities Uppsala, Padova, Ancona and Paris via MYOAGE and ENGAGE research consortia (EU\/FP7). The HRT specific knowledge, both in relation to sarcopenia and other health outcomes will add our understanding, when evaluating the possible positive and negative effects of HRT. This study will increase our knowledge of the genetic and molecular mechanisms behind sarcopenia and responsiveness to interventions upon aging. Consequently, the results are crucial for developing rational preventive and therapeutic measures and interventions for old age disability, which can be applied e.g. at health and rehabilitation centers.\r\n\r\nFunding<\/strong>\r\nFinnish Ministry of Culture and Education, Academy of Finland, MYOAGE\r\n\r\nResearch group<\/strong>\r\nPrincipal Investigator<\/i>\r\nAdjunct professor, PhD Vuokko Kovanen, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\n\r\nDoctoral thesis<\/a><\/strong>\r\n\r\nSelected publications <\/strong>\r\n\r\n \t
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