This is a joint research project involving 19 European partners and funded by EU (FP7). MYOAGE is divided into 11 work packages (WP) from which WP9: Hormones and muscle weakness is leaded by Gerontology Research Center, University of Jyv\u00e4skyl\u00e4. Objectives of the WP9 is to investigate the role of sex hormones, estrogens and testosterone, in causing the aging related loss of muscle mass and function, to assess the effects of hormonal supplementation on restoring muscle mass and function in older men and women, to assess the effects of hormone replacement therapy on myosin synthesis, expression and function in postmenopausal women and to investigate the mechanism of hormone action on muscle IGF-1 signaling pathways. In addition to WP9, Gerontology Research Center is involved in the WP2: Physiological and functional evaluation, WP5: Inflammation and oxidative stress and WP8: Exercise and diet.<\/p>\n
Funding<\/strong> Research group<\/strong> Senior researchers<\/i><\/strong> Postdoctoral researchers<\/i><\/strong> Doctoral<\/a> thesis<\/a><\/strong><\/p>\n Selected publications<\/strong> Finni T, Noorkoiv M, P\u00f6ll\u00e4nen E, Ronkainen PH, Al\u00e9n M, Kaprio J, Kovanen V, Sipil\u00e4 S. Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy. Muscle Nerve, 2011 Nov;44(5):769-75.<\/p>\n Ronkainen PH, P\u00f6ll\u00e4nen E, Al\u00e9n M, Pitk\u00e4nen R, Puolakka J, Kujala UM, Kaprio J, Sipil\u00e4 S, Kovanen V. Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. Aging Cell. 2010 Dec;9(6):1098-110.<\/p>\n Collaborators<\/strong> INSERM, FR (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Gillian Butler-Browne), Manchester Metropolitan University, UK (Marco Narici), Institute of Sports Medicine, DK (Michael Kjaer), Uppsala University, SE (Lars Larsson), Bologna University, IT (Claudio Franceschi)[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false,"raw":"[vc_row][vc_column][vc_column_text]Aim is first to identify the relative importance of muscle weakness in the European population in order to propose standards to define healthy ageing in order to identify age-related muscle weakness; secondly to identify molecular mechanisms and pathways which are responsible for this weakness and which may be targeted to combat age related muscle weakness, and thirdly to identify therapeutic strategies to prevent muscle loss and weakness, increase health span and enhance recovery following injury or immobilization.\r\n\r\nThis is a joint research project involving 19 European partners and funded by EU (FP7). MYOAGE is divided into 11 work packages (WP) from which WP9: Hormones and muscle weakness is leaded by Gerontology Research Center, University of Jyv\u00e4skyl\u00e4. Objectives of the WP9 is to investigate the role of sex hormones, estrogens and testosterone, in causing the aging related loss of muscle mass and function, to assess the effects of hormonal supplementation on restoring muscle mass and function in older men and women, to assess the effects of hormone replacement therapy on myosin synthesis, expression and function in postmenopausal women and to investigate the mechanism of hormone action on muscle IGF-1 signaling pathways. In addition to WP9, Gerontology Research Center is involved in the WP2: Physiological and functional evaluation, WP5: Inflammation and oxidative stress and WP8: Exercise and diet.\r\n\r\nFunding<\/strong>\r\n<\/b>European Union (FP7)\r\n\r\nResearch group<\/strong>\r\n<\/b>Principal investigator\r\n<\/i><\/b>Professor Sarianna Sipil\u00e4, sarianna.sipila@jyu.fi, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\n\r\nSenior researchers<\/i><\/strong>\r\n<\/i><\/b><\/b>Vuokko Kovanen, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\nTaija Juutinen, Department of Exercise Biology, University of Jyv\u00e4skyl\u00e4\r\nUrho Kujala, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\n\r\nPostdoctoral researchers<\/i><\/strong>\r\n<\/i><\/b>Eija P\u00f6ll\u00e4nen\r\nElina\u00a0Sillanp\u00e4\u00e4\r\n\r\nDoctoral<\/a> thesis<\/a><\/strong>\r\n\r\nSelected publications<\/strong>\r\n<\/b>Ahtiainen M, P\u00f6ll\u00e4nen E, Ronkainen PH, Alen M, Puolakka J, Kaprio J, Sipil\u00e4 S, Kovanen V. Age and estrogen-based hormone therapy affect systemic and local IL-6 and IGF-1 pathways in women. Age (Dordr). 2011 Aug 16. [Epub ahead of print]\r\n Finni T, Noorkoiv M, P\u00f6ll\u00e4nen E, Ronkainen PH, Al\u00e9n M, Kaprio J, Kovanen V, Sipil\u00e4 S. Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy. Muscle Nerve, 2011 Nov;44(5):769-75.<\/p>\r\nRonkainen PH, P\u00f6ll\u00e4nen E, Al\u00e9n M, Pitk\u00e4nen R, Puolakka J, Kujala UM, Kaprio J, Sipil\u00e4 S, Kovanen V. Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. Aging Cell. 2010 Dec;9(6):1098-110.\r\n\r\nCollaborators<\/strong>\r\n<\/b>MyoAge consortium\r\n\r\nINSERM, FR (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Gillian Butler-Browne), Manchester Metropolitan University, UK (Marco Narici), Institute of Sports Medicine, DK (Michael Kjaer), Uppsala University, SE (Lars Larsson), Bologna University, IT (Claudio Franceschi)[\/vc_column_text][\/vc_column][\/vc_row]"},"excerpt":{"rendered":"[vc_row][vc_column][vc_column_text] Tutkimusprojektin tarkoituksena on selvitt\u00e4\u00e4 mik\u00e4 on lihasheikkouden suhteellinen osuus eurooppalaisessa v\u00e4est\u00f6ss\u00e4, jotta voidaan laatia ik\u00e4\u00e4nnytt\u00e4ess\u00e4 terveen\u00e4 ja toimintakykyisen\u00e4 pysymist\u00e4 kuvaavia ja edist\u00e4vi\u00e4 standardeja ja niiden perusteella m\u00e4\u00e4ritell\u00e4 ik\u00e4\u00e4n liittyv\u00e4n lihasheikkouden merkityst\u00e4 koko Euroopassa. T\u00e4m\u00e4n lis\u00e4ksi identifioidaan molekylaarisia mekanismeja ja…","protected":false,"raw":""},"author":1,"featured_media":0,"parent":5279,"menu_order":8,"comment_status":"open","ping_status":"open","template":"templates\/left-sidebar.php","meta":{"_mi_skip_tracking":false,"_fi_post_content":"[vc_row][vc_column][vc_column_text]\r\n Tutkimusprojektin tarkoituksena on selvitt\u00e4\u00e4 mik\u00e4 on lihasheikkouden suhteellinen osuus eurooppalaisessa v\u00e4est\u00f6ss\u00e4, jotta voidaan laatia ik\u00e4\u00e4nnytt\u00e4ess\u00e4 terveen\u00e4 ja toimintakykyisen\u00e4 pysymist\u00e4 kuvaavia ja edist\u00e4vi\u00e4 standardeja ja niiden perusteella m\u00e4\u00e4ritell\u00e4 ik\u00e4\u00e4n liittyv\u00e4n lihasheikkouden merkityst\u00e4 koko Euroopassa. T\u00e4m\u00e4n lis\u00e4ksi identifioidaan molekylaarisia mekanismeja ja reaktioreittej\u00e4, jotka vaikuttavat lihasheikkouden syntyyn ja, joihin voitaisiin kohdentaa sen vatustamiseen t\u00e4ht\u00e4\u00e4vi\u00e4 toimia sek\u00e4 kehitt\u00e4\u00e4 toimintamalleja, jotka lis\u00e4isiv\u00e4t terveen\u00e4 ja toimintakykyisen\u00e4 s\u00e4ilymist\u00e4 ik\u00e4\u00e4nnytt\u00e4ess\u00e4 sek\u00e4 edist\u00e4isiv\u00e4t esim. luunmurtumasta johtuvasta liikkumattomuudesta toipumista.<\/p>\r\n MYOAGE-projekti on 19 eurooppalaisen tutkimusorganisaation yhteinen konsortio, jota rahoittaa Euroopan unioni. Tutkimusprojekti on jaettu 11 ty\u00f6kokonaisuuteen (engl. work package; WP), joista WP9: Hormonit ja lihasheikkous on Gerontologian tutkimuskeskuksen Jyv\u00e4skyl\u00e4n yliopiston yksik\u00f6n johtama. WP9:n tavoitteena on tutkia sukupuolihormonien, estrogeenin ja testosteronin, merkityst\u00e4 ik\u00e4\u00e4ntyvien ihmisten lihaskadon ja toiminnanvajausten ilmentymisen kannalta, m\u00e4\u00e4ritt\u00e4\u00e4 hormonaalisen supplementaation merkityst\u00e4 lihasmassan ja \u2013toimintojen yll\u00e4pit\u00e4j\u00e4n\u00e4 sek\u00e4 tutkia hormonikorvaushoidon vaikutuksia IGF-1 signalointiin ja myosiinin synteesiin, ilmentymiseen ja toimintaan vaihdevuosi-i\u00e4n ohittaneilla naisilla. WP9:n lis\u00e4ksi Gerontologian tutkimuskeskus on voimakkaasti mukana WP2:ssa: Fysiologinen ja toiminnallinen arviointi, WP5:ss\u00e4: Tulehdus ja oksidatiivinen stressi sek\u00e4 WP8:ssa: Liikkuminen ja ruokavalio.<\/p>\r\n Rahoittaja<\/strong>\r\n<\/b>Euroopan unionin 7. puiteohjelma<\/p>\r\n Tutkimusryhm\u00e4<\/strong>\r\n<\/b>Vastuullinen tutkija\r\n<\/i><\/b>Professori Sarianna Sipil\u00e4, sarianna.sipil\u00e4@jyu.fi, terveystieteiden laitos, Jyv\u00e4skyl\u00e4n yliopisto<\/p>\r\n Senioritutkijat\r\n<\/i><\/b>Vuokko Kovanen, terveystieteiden laitos, Jyv\u00e4skyl\u00e4n yliopisto\r\nTaija Juutinen, liikuntabiologian laitos, Jyv\u00e4skyl\u00e4n yliopisto\r\nUrho Kujala, terveystieteiden laitos, Jyv\u00e4skyl\u00e4n yliopisto<\/p>\r\n Tutkijatohtorit\r\n<\/i><\/b>Eija P\u00f6ll\u00e4nen\r\nElina\u00a0Sillanp\u00e4\u00e4<\/p>\r\n V\u00e4it\u00f6skirjat<\/b>\u00a0<\/a><\/p>\r\n Keskeiset julkaisut<\/strong>\r\n<\/b>Ahtiainen M, P\u00f6ll\u00e4nen E, Ronkainen PH, Alen M, Puolakka J, Kaprio J, Sipil\u00e4 S, Kovanen V. Age and estrogen-based hormone therapy affect systemic and local IL-6 and IGF-1 pathways in women. Age (Dordr). 2011 Aug 16. [Epub ahead of print]<\/p>\r\n Finni T, Noorikov M, P\u00f6ll\u00e4nen E, Ronkainen PH, Al\u00e9n M, Kaprio J, Kovanen V, Sipil\u00e4 S. Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy. Muscle Nerve. 2011 Nov;44(5):769-75<\/p>\r\n Ronkainen PH, P\u00f6ll\u00e4nen E, Al\u00e9n M, Pitk\u00e4nen R, Puolakka J, Kujala UM, Kaprio J, Sipil\u00e4 S, Kovanen V. Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. Aging Cell. 2010 Dec;9(6):1098-110.<\/p>\r\n Yhteisty\u00f6tahoja<\/strong>\r\n<\/b>Koko MyoAge konsortio<\/p>\r\n Erityisesti WP9:ss\u00e4 mukana ovat INSERM, FR (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Gillian Butler-Browne), Manchester Metropolitan University, UK (Marco Narici), Institute of Sports Medicine, DK (Michael Kjaer) and Uppsala University, SE (Lars Larsson)<\/p>\r\nWP2:n toimintaa koordinoi Manchester Metropolitan University, UK (Marco Narici)\r\n WP5:n toimintaa koordinoi Bologna University, IT (Claudio Franceschi)<\/p>\r\n WP8:n toimintaa koordinoi Manchester Metropolitan University, UK (Marco Narici)<\/p>\r\n[\/vc_column_text][\/vc_column][\/vc_row]","_fi_post_name":"ikaantymiseen-liittyvan-lihasheikkouden-ymmartaminen-ja-ehkaisy-myoage","_fi_post_excerpt":"","_fi_post_title":"Ik\u00e4\u00e4ntymiseen liittyv\u00e4n lihasheikkouden ymm\u00e4rt\u00e4minen ja ehk\u00e4isy (MYOAGE)","_en_post_content":"[vc_row][vc_column][vc_column_text]Aim is first to identify the relative importance of muscle weakness in the European population in order to propose standards to define healthy ageing in order to identify age-related muscle weakness; secondly to identify molecular mechanisms and pathways which are responsible for this weakness and which may be targeted to combat age related muscle weakness, and thirdly to identify therapeutic strategies to prevent muscle loss and weakness, increase health span and enhance recovery following injury or immobilization.\r\n\r\nThis is a joint research project involving 19 European partners and funded by EU (FP7). MYOAGE is divided into 11 work packages (WP) from which WP9: Hormones and muscle weakness is leaded by Gerontology Research Center, University of Jyv\u00e4skyl\u00e4. Objectives of the WP9 is to investigate the role of sex hormones, estrogens and testosterone, in causing the aging related loss of muscle mass and function, to assess the effects of hormonal supplementation on restoring muscle mass and function in older men and women, to assess the effects of hormone replacement therapy on myosin synthesis, expression and function in postmenopausal women and to investigate the mechanism of hormone action on muscle IGF-1 signaling pathways. In addition to WP9, Gerontology Research Center is involved in the WP2: Physiological and functional evaluation, WP5: Inflammation and oxidative stress and WP8: Exercise and diet.\r\n\r\nFunding<\/strong>\r\n<\/b>European Union (FP7)\r\n\r\nResearch group<\/strong>\r\n<\/b>Principal investigator\r\n<\/i><\/b>Professor Sarianna Sipil\u00e4, sarianna.sipila@jyu.fi, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\n\r\nSenior researchers<\/i><\/strong>\r\n<\/i><\/b><\/b>Vuokko Kovanen, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\nTaija Juutinen, Department of Exercise Biology, University of Jyv\u00e4skyl\u00e4\r\nUrho Kujala, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4\r\n\r\nPostdoctoral researchers<\/i><\/strong>\r\n<\/i><\/b>Eija P\u00f6ll\u00e4nen\r\nElina\u00a0Sillanp\u00e4\u00e4\r\n\r\nDoctoral<\/a> thesis<\/a><\/strong>\r\n\r\nSelected publications<\/strong>\r\n<\/b>Ahtiainen M, P\u00f6ll\u00e4nen E, Ronkainen PH, Alen M, Puolakka J, Kaprio J, Sipil\u00e4 S, Kovanen V. Age and estrogen-based hormone therapy affect systemic and local IL-6 and IGF-1 pathways in women. Age (Dordr). 2011 Aug 16. [Epub ahead of print]\r\n Finni T, Noorkoiv M, P\u00f6ll\u00e4nen E, Ronkainen PH, Al\u00e9n M, Kaprio J, Kovanen V, Sipil\u00e4 S. Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy. Muscle Nerve, 2011 Nov;44(5):769-75.<\/p>\r\nRonkainen PH, P\u00f6ll\u00e4nen E, Al\u00e9n M, Pitk\u00e4nen R, Puolakka J, Kujala UM, Kaprio J, Sipil\u00e4 S, Kovanen V. Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. Aging Cell. 2010 Dec;9(6):1098-110.\r\n\r\nCollaborators<\/strong>\r\n<\/b>MyoAge consortium\r\n\r\nINSERM, FR (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Gillian Butler-Browne), Manchester Metropolitan University, UK (Marco Narici), Institute of Sports Medicine, DK (Michael Kjaer), Uppsala University, SE (Lars Larsson), Bologna University, IT (Claudio Franceschi)[\/vc_column_text][\/vc_column][\/vc_row]","_en_post_name":"myoage","_en_post_excerpt":"","_en_post_title":"Understanding and combating age related muscle weakness (MYOAGE)","edit_language":"en","footnotes":""},"class_list":["post-131","page","type-page","status-publish","hentry","entry","no-media"],"_links":{"self":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/pages\/131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/comments?post=131"}],"version-history":[{"count":5,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/pages\/131\/revisions"}],"predecessor-version":[{"id":6741,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/pages\/131\/revisions\/6741"}],"up":[{"embeddable":true,"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/pages\/5279"}],"wp:attachment":[{"href":"https:\/\/www.gerec.fi\/en\/wp-json\/wp\/v2\/media?parent=131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/b>European Union (FP7)<\/p>\n
\n<\/b>Principal investigator
\n<\/i><\/b>Professor Sarianna Sipil\u00e4, sarianna.sipila@jyu.fi, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4<\/p>\n
\n<\/i><\/b><\/b>Vuokko Kovanen, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4
\nTaija Juutinen, Department of Exercise Biology, University of Jyv\u00e4skyl\u00e4
\nUrho Kujala, Department of Health Sciences, University of Jyv\u00e4skyl\u00e4<\/p>\n
\n<\/i><\/b>Eija P\u00f6ll\u00e4nen
\nElina\u00a0Sillanp\u00e4\u00e4<\/p>\n
\n<\/b>Ahtiainen M, P\u00f6ll\u00e4nen E, Ronkainen PH, Alen M, Puolakka J, Kaprio J, Sipil\u00e4 S, Kovanen V. Age and estrogen-based hormone therapy affect systemic and local IL-6 and IGF-1 pathways in women. Age (Dordr). 2011 Aug 16. [Epub ahead of print]\n
\n<\/b>MyoAge consortium<\/p>\n